Molecular heterogeneity of antigen- or idiotype-induced anti-thyroglobulin monoclonal autoantibodies
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چکیده
منابع مشابه
Cross-reactive Idiotype of Human Anti-Thyroglobulin Autoantibodies
Pooled normal polyspecific IgG for therapeutic use (IVIg) contain anti-idiotypes against idiotypic determinants expressed by autoantibodies from patients with a variety of autoimmune diseases. In the present study, antiidiotypes in IVIg are shown to recognize a cross-reactive idiotype on human anti-thyroglobulin (TG) autoantibodies, that was defined by heterologous antiidiotypic antibodies, ter...
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Anti-idiotypic antibodies were prepared against two monoclonal anti-H-2Kk antibodies, 11-4.1 and 3-83P. These reagents were used to examine idiotype (Id) expression on anti-H-2Kk antibodies induced by the in vivo administration of the anti-idiotypic antibodies and/or H-2Kk antigen. Treatment of BALB/c mice with anti-Id induced both antigen-binding and nonantigen-binding Id-positive molecules in...
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BALB/c mice were immunized with either NP-3 or NP-4, two anticarcinoembryonic antigen murine monoclonal antibodies. Each animal produced anti-idiotype antibodies to the corresponding immunogen and no cross-reactivity between anti-NP-3 sera and anti-NP-4 sera was detected. Hybridomas were produced from these animals and two IgG1 anti-idiotype monoclonal antibodies were obtained: CM1 specific for...
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The current acceptable notion regarding autoimmune diseases is that autoimmunity and autoimmune diseases are autoantigen driven. This pathogenetic mechanism is very much conceivable according to theories in classical immunology, namely, if there is a reactive antibody, it must have been generated upon immunization with an antigen. Definitely, a support to this notion is gained from the fact s...
متن کاملDevelopment of syngeneic monoclonal anti-idiotype antibodies to mouse monoclonal anti-asialoglycoprotein receptor antibody.
Anti-idiotype antibodies (Ab2) play an important role in the homeostasis of immune responses and are related to the development and the disease activity of certain autoimmune diseases. The asialoglycoprotein receptor (ASGPR) is considered one of the target antigens in the pathogenesis of autoimmune chronic active hepatitis (AIH). We previously developed a mouse monoclonal antibody (clone 8D7) w...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1995.tb03723.x